|
| Section1 = | Reaction = }} The Wittig reaction or Wittig olefination is a chemical reaction of an aldehyde or ketone with a triphenyl phosphonium ylide (often called a Wittig reagent) to give an alkene and triphenylphosphine oxide. The Wittig reaction was discovered in 1954 by Georg Wittig, for which he was awarded the Nobel Prize in Chemistry in 1979. It is widely used in organic synthesis for the preparation of alkenes.〔Maercker, A. ''Org. React.'' 1965, ''14'', 270–490. (Review)〕〔W. Carruthers, ''Some Modern Methods of Organic Synthesis'', Cambridge University Press, Cambridge, UK, 1971, 81–90. (ISBN 0-521-31117-9)〕 It should not be confused with the Wittig rearrangement. Wittig reactions are most commonly used to couple aldehydes and ketones to singly substituted phosphine ylides. With unstabilised ylides this results in almost exclusively the Z-alkene product. In order to obtain the E-alkene, stabilised ylides are used or unstabilised ylides using the Schlosser modification of the Wittig reaction can be performed. ==Reaction mechanism== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Wittig reaction」の詳細全文を読む スポンサード リンク
|